Nikki Glaser Kicks Off Golden Globes with Sharp Jokes About Diddy, Ben Affleck, and Hollywood’s Night of Glitz

Comedian Nikki Glaser brought her trademark humor to the stage as she hosted this year’s Golden Globe Awards, kicking off the night with a bold and hilarious opening monologue that poked fun at Hollywood’s biggest names. Held at the iconic Beverly Hilton hotel in Beverly Hills, California, the event brought together the who’s who of the entertainment industry — but Glaser’s jokes were the main attraction in the early moments of the evening.

A Playful Nod to Hollywood’s Latest Trend

Glaser, 40, wasted no time setting the tone for the evening, opening the show with a quip about Hollywood’s obsession with weight-loss medication. She jokingly declared that the Golden Globes was “Ozempic’s biggest night,” referring to the controversial diabetes drug that has become a go-to for some celebrities trying to shed pounds quickly. The line drew laughs and set the stage for what would be a monologue full of sharp observations and edgy humor.

Zendaya’s “Challengers” Gets a Cheeky Shoutout

Glaser then turned her attention to Zendaya, one of Hollywood’s rising stars, who recently earned acclaim for her role in Challengers. The movie follows a tennis player caught in a steamy love triangle involving her husband and ex-boyfriend, and Glaser didn’t miss the opportunity to crack a joke.

“That movie was more sexually charged than Diddy’s credit card,” she quipped, earning gasps and laughter from the crowd. Adding to the punchline, she jokingly lamented, “I know … I’m upset, too. The after-party isn’t going to be as good.”

The Diddy reference comes at an interesting time, as the music mogul recently made headlines for more serious reasons. Back in March, Sean “Diddy” Combs’ homes in Los Angeles and Miami were raided as part of a federal human trafficking investigation, a story that sent shockwaves through the entertainment world. While Glaser didn’t delve into the details of the controversy, her lighthearted jab reminded the audience that even the industry’s biggest figures aren’t safe from her comedic barbs.

A Dig at Ben Affleck and Stanley Tucci

The Gone Girl actor Ben Affleck also found himself in Glaser’s crosshairs. Known for her quick wit and no-holds-barred approach, Glaser made light of Affleck’s well-documented ups and downs in the public eye, although the specifics of the joke were left to the imagination.

Stanley Tucci, another Hollywood favorite, wasn’t spared either. Glaser joked that if the event needed another host, Tucci could step in — but with a twist. “No baby oil this year, just olive oil,” she said, delivering one of the more offbeat moments of her monologue.

Balancing Edginess with Charm

Throughout her opening remarks, Glaser managed to strike a balance between playful roasting and genuine admiration for the stars in attendance. Her jokes may have been edgy, but they were delivered with a charm that kept the audience laughing rather than squirming.

The Golden Globes have long been known for their lighthearted, less formal approach compared to other award shows, and Glaser’s performance fit perfectly into that tradition. Her ability to poke fun at the industry while still celebrating its achievements is part of what made her hosting debut so memorable.

A Night to Remember

As the evening continued, Glaser’s monologue remained a talking point, sparking conversations both inside the Beverly Hilton ballroom and across social media. Fans praised her fearless humor, while others debated the appropriateness of some of her jokes.

One thing is certain: Nikki Glaser made sure the 2025 Golden Globe Awards started with a bang. Her opening monologue reminded everyone why humor and awards season go hand in hand, even when the jokes hit close to home.

As Hollywood reflects on another year of achievements, Glaser’s performance will undoubtedly be remembered as one of the night’s highlights — a moment where comedy met glamour in the most entertaining way possible.