
Understanding Depression and Anxiety
Depression and anxiety are two of the most commonly occurring mental disorders, with many individuals suffering from anxiety and depression. It is estimated that one in six American adults will have depression in their lifetime. 1
It is also estimated that 19.1% of the US adult population is struggling with an anxiety disorder.
The Relationship Between Anxiety and Depression
Anxiety and depression are related and are often co-occurring. Both anxiety and depression are internalizing disorders, and both share functional and structural brain alterations in pathways involving emotional regulation, executive functioning, and cognitive control. Anxiety and depression typically occur during development, with anxiety emerging during preadolescence and early adolescence. Depression occurs a little later in development, usually following anxiety, emerging during adolescence and early to mid-adulthood.

Major Causes of Depression
Death or a Loss
Grief and loss, although natural causes, can increase the risk of depression. When grief is prolonged or leads to symptoms affecting life functioning, it can indicate depression.
Brain Chemistry
One of the most widely accepted causes of depression is changes in brain chemistry. These changes are related explicitly to neurotransmitters dopamine, serotonin, and norepinephrine. Individuals with imbalances in these neurotransmitters can experience symptoms of depression.
Abuse
Abuse in childhood is a strong predictor of depression later in life. In a recent study of hospitalized individuals with depression, 75.6% of chronically depressed patients reported having a significant history of childhood trauma and abuse. Abuse in adulthood can also cause depression.
Hormone Levels
Hormonal imbalances can also cause depression. Hormones, specifically those related to the thyroid, can be factors in depression. Because of this, symptoms of depression are related to thyroid conditions. For women especially, conditions related to the menstrual cycle, which are hormonal in origin, can also cause depression.
Medical Conditions
Certain medical conditions can also be related to depression. Serious illness, thyroid conditions, cancer, chronic pain, heart disease, lupus, diabetes, HIV, and multiple sclerosis can increase the risk of depression.
Genetics
Depression is a heritable disease, meaning that it has a genetic component. Having a family history of depression can increase your risk. It is estimated that depression is moderately heritable, at 40%.

Major Causes of Anxiety
Stress at Work
Work stress can trigger anxiety. According to the 2021 Mind the Workplace report, 85% of respondents reported that job stress affected their mental health. Job stress can be due to keeping up with unrealistic demands, presenting, and interpersonal relationships. If the anxiety continues outside the workplace and is present on days off, it may indicate an anxiety disorder.
Stress from School
Similar to job stress, academic stress can trigger anxiety. Academic and peer-related pressure can cause stress for younger individuals. Additionally, anxiety is a disorder that appears in pre to mid-adolescence. If stress related to school is causing anxiety, and it doesn’t resolve when the individual is no longer in school, this may indicate an anxiety disorder.
Chemical Imbalance
Chemical imbalances have also been cited as the cause of anxiety. Anxiety is a disorder that affects neurotransmitters, including serotonin, norepinephrine, and gamma amino butyric acid. Individuals with anxiety typically show changes in the levels of these brain chemicals.
nvironmental Factors
Individuals with no genetic predisposition to anxiety can still develop an anxiety disorder from environmental factors alone. Unsupportive stressful environments over time can be overwhelming and trigger anxiety. Additionally, traumatic early life experiences or a neglectful, abusive home environment are risk factors for anxiety.
Withdrawal From an Illicit Substance
Withdrawal from illicit substances such as heroin, methamphetamine, and other drugs can cause anxiety. Symptoms of anxiety from withdrawal can be lasting, especially in post-acute withdrawal syndrome (PAWS), and can develop into an anxiety disorder.
Common Symptoms of Depression and Anxiety
- Irrational Worries or Fears
- Irritation or Frustration
- Fatigue
- Headaches
- Changes in Eating Habits
- Difficulty in Concentrating
- Sadness
- Worthlessness




Comments
There are no comments for this story
Be the first to respond and start the conversation.