The Science Behind Polynucleotides

Skincare has gone way beyond slapping on some moisturizer and hoping for the best. These days, science is stepping in bringing us game-changing treatments that actually help our skin heal not just cover up imperfections. One of the latest breakthroughs? Polynucleotides. Yeah, the name sounds straight out of a biology textbook but don’t tune out just yet—this stuff is the real deal when it comes to skin repair and regeneration.

Wait, What Are Polynucleotides?

Alright let’s keep this simple. Polynucleotides are basically tiny DNA fragments (usually from salmon—stay with me) that help your skin heal itself. They kickstart your body’s natural repair process, boosting collagen, reducing inflammation, and improving hydration. Instead of just filling in fine lines like Botox or plumping your skin like hyaluronic acid, polynucleotide treatment actually improves your skin’s structure from the inside out.

Think of them like personal trainers for your skin cells pushing them to work harder and smarter. The result? Healthier, smoother and more resilient skin over time.

The Magic of Microneedling + Polynucleotides

Microneedling treatments have already made a name for themselves in skincare. By creating tiny micro-injuries in the skin microneedling forces your body to repair itself producing more collagen and elastin in the process. But when you add polynucleotide injections to the mix? That’s when things get seriously exciting.

Microneedling opens up pathways in your skin, allowing polynucleotides to absorb more effectively. Instead of just hanging out on the surface, they go deep, triggering intense skin regeneration. If you’ve been battling acne scars, uneven texture, or dull skin, this combination might just be the skin refresh you’ve been looking for.

What’s the Deal With Polynucleotide Treatments?

Unlike fillers that give instant results but fade over time, polynucleotide therapy is more about the long game. It’s a gradual process, but the improvements are real and lasting.

A typical treatment plan includes a few sessions spread out over several weeks. Each session involves a few quick injections—nothing crazy—and while you might have some redness afterward, it’s a small price to pay for the glow-up that’s coming. Over time, your skin will start producing more collagen, looking smoother, firmer and more hydrated.

Who’s a Good Candidate for This?

Pretty much anyone who wants healthier skin. Whether you’re into skincare or just looking for something that actually works, polynucleotide therapy is worth considering. It’s especially great if you’re dealing with:

• Acne scars – Helps smooth out uneven texture and remodel damaged skin.
• Dry, dull skin – Hydrates deeply and boosts elasticity.
• Fine lines and wrinkles – Naturally softens signs of aging over time.
• Sensitive, irritated skin – Soothes redness and inflammation without harsh side effects.

And if you’re someone who can’t handle aggressive treatments like lasers or deep peels, polynucleotide injections are gentle enough to get results without wrecking your skin barrier.

Post-Treatment: How to Make the Most of It

Like any good skincare treatment, how you care for your skin afterward makes a big difference. Here’s what to do (and what not to do):

• Hydrate, hydrate, hydrate. Polynucleotides help your skin hold moisture better than ever, so load up on water and use a solid hydrating serum.
• Skip the harsh stuff. No retinoids or heavy exfoliants for at least a few days—your skin needs time to recover.
• Keep your hands off. Seriously, don’t poke, pick, or mess with your skin. Let it heal properly.
• SPF is your new best friend. Your skin is in repair mode, which makes it extra sensitive to the sun. Protect it with a good sunscreen every single day.

Is Polynucleotide Therapy the Future of Skincare?

Skincare trends come and go (remember when people swore by putting toothpaste on pimples?), but this one seems like it’s here to stay. Unlike gimmicky quick fixes, polynucleotide therapy is backed by science and actually improves your skin’s foundation—not just the surface.

Dermatologists are even looking into polynucleotides for more than just skincare, with potential applications for stretch marks, wound healing, and even hair regrowth. Who knew salmon DNA could do so much?

So, if you’re looking for a treatment that works with your skin, not against it, polynucleotide therapy might just be the upgrade your routine has been waiting for. Science-backed, skin-approved and full of long-term benefits—what’s not to love?

See for further details by visiting Mesotherapy With Polynucleotides vs. Mesotherapy Without Polynucleotides: What’s the Difference? | MDA