Brian McNaughton Interview on Vocal Media

In the quaint town of Phoenixville, Pennsylvania, nestled among rolling hills and historic charm, lives a man whose work could reshape the future of medicine. Brian McNaughton, an educator and scientific professional, differs from your average small-town resident. His days are filled with the intricate dance of protein evolution, the mystery of intracellular biologics delivery, and the cutting-edge world of nanobody-based immunotherapeutic discovery.

McNaughton's journey began at Indiana University of Pennsylvania, where he earned his Bachelor of Science in Chemistry. It was here, amidst the clinking of test tubes and the hum of centrifuges, that Brian first felt the pull of scientific discovery. But it wasn't enough. Hungry for more, he dove headfirst into a doctoral program at the University of Rochester, emerging with a Ph.D. in Chemistry, specializing in Chemical Biology.

Fresh-faced and brimming with ideas, Brian landed a coveted position as a Postdoctoral Fellow at Harvard University. It was a whirlwind time, resulting in twelve published research papers that would set the tone for his career. But McNaughton wasn't content to rest on his laurels. He knew that to make a difference truly, he needed to pass on his knowledge and passion to the next generation.

This drive led him to Colorado State University, where he spent nearly a decade as an Associate Professor of Chemistry and Biochemistry/Molecular Biology. Here, Brian didn't just teach; he inspired. His Modern Organic Chemistry, Physical Organic Chemistry, Immunology, and Molecular Biology classes weren't mere lectures – they were launching pads for future scientists.

Now, as a Senior Fellow and Adjunct Professor, McNaughton continues to shape young minds while simultaneously pushing the boundaries of science. His current research, funded by an NIH Research Grant, focuses on developing novel protein/RNA interactions. It's complex stuff, but for Brian, it's all part of his lifelong mission to create the next generation of therapeutics.

This isn't McNaughton's first rodeo with groundbreaking research. In 2021, he completed a project on "SARS-CoV-2 Entry Inhibitors as Therapeutics and Prophylaxis," a timely study in the face of a global pandemic. His work has led to publications with titles that sound like science fiction but represent genuine advancements: "An Evolved RNA Recognition Motif That Suppresses HIV-1 Tat/TAR-Dependent Transcription" and "Resurfaced Shape Complementary Proteins That Selectively Bind the Oncoprotein Gankyrin."

But Brian McNaughton is more than just a brilliant scientist. He's a Renaissance man in the truest sense. When he's not in the lab or classroom, you might find him on the golf course, perfecting his swing. Or perhaps he's out on a hiking trail, breathing in the crisp Pennsylvania air and finding inspiration in nature's wonders.

Family is at the heart of everything Brian does. He cherishes every moment spent with his children, eager to show them the world beyond Phoenixville. A passionate traveler, McNaughton believes that experiencing different cultures and cuisines is essential to broadening one's perspective.

And then there's the art. When the lab coat comes off in the quiet evening hours, Brian often finds himself in front of a canvas. Painting is more than just a hobby for him – it's a form of expression, a way to process the complexities of his scientific work through color and form.

Brian McNaughton is a man of contrasts. He's equally at home peering into a microscope as he is gazing at a sunset. He can discuss the intricacies of RNA-targeted protein and peptide drug discovery with the same enthusiasm as he talks about his latest culinary adventure. This blend of scientific rigor and creative spirit makes him not just a great researcher but a truly inspiring human being.

Brian McNaughton is likely still at work as the sun sets over Phoenixville, casting long shadows across the historic buildings. Whether he's mentoring a student, jotting down ideas for his following research paper, or adding the finishing touches to a painting, one thing is sure – he's constantly pushing forward, always seeking to make the world a little bit better, one discovery at a time.

Our Interview With Brian McNaughton

What inspired you to pursue a career in your field?

-My high school chemistry teacher was fantastic. Additionally, the realization that biotechnology is a patient-centered industry and technology we develop can ultimately improve human health.

What do you think are the most pressing challenges facing your industry today?

-Technology development will alway present a hurdle to the biotechnology industry, as well as implementation of new technologies into pharmaceutical workflows.

What role do you believe that collaboration plays in advancing scientific research?

-No single scientists is well versed in the diverse array of research areas required for high-impact research. Therefore, collaboration is a requirement for high-impact research.

What strategies do you recommend for fostering curiosity and a passion for science among the next generation of students?

-Get into a laboratory setting as soon as possible.

How can education keep up with the rapidly changing scientific field?

-Development and integration of new courses specifically focused on new technologies, new therapeutic approaches, and new therapeutic mechanisms of action

What advice would you give to young professionals wanting to pursue a career in your field?

-Get into a laboratory environment as soon as you can, and have a meaningful number (3-4) long term rotations through diverse labs. Doing the actual science is the best way to see if it’s a good fit for you.

What is the best way to stay informed about the latest advancements in science and education?

-Take the time to dedicate a few hours per week to reading literature and participate in a group – much like a book club – with the role of staying up to date in literature relevant to your research interests