What is Persistent Corneal Epithelial Defects in 2021?

Corneal epithelial defects are a focal area of epithelial (outermost corneal layer) loss; can be due to mechanical trauma, corneal dryness, neurotrophic cornea, post‐surgical changes, or any other of a variety of etiologies. The persistent corneal epithelial defect can result in corneal haze, infectious and sterile keratitis, stromal melting, perforation, irregular astigmatism, loss of vision, and loss of the eye.

Currently, the treatment options include a step‐wise approach to standard therapies for PCEDs. The steps may sometimes be skipped based on individual circumstances. The first step involves support of the ocular surface with aggressive lubrication using preservative‐free artificial tears or lubricating ointment every 1–2 hour. On occasion, epithelial defects fail to heal because the patient is using topical medications that contain preservatives toxic to the corneal epithelium, such as benzalkonium chloride.

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Moreover, soft therapeutic contact lenses serve to protect the corneal surface from mechanical trauma from the eyelids. A soft contact lens with high oxygen permeability (such as a silicone hydrogel) is chosen to reduce complications, such as corneal edema and neovascularization. A 16‐ or 18‐mm Kontur lens (Kontur Lens) is often effective; its diameter is greater than the limbal margin, and its thickness provides stability. Ointments should be discontinued for patients using a bandage contact lens (BCL). It takes approximately 7 days after the epithelium heals for adhesions to form. However, if the stroma is involved, it may take 8 weeks or more for epithelial cells to adhere to the underlying basement membrane/stroma. It may be desirable to keep the BCL in the eye for approximately 1 week after the epithelium heals, but BCLs are sometimes kept in place for as long as two or three months.

Tarsorrhaphy involves the partial or complete closure of the eyelid fissure to allow the ocular surface to heal itself. This minor in‐office procedure can be a very effective treatment for persistent epithelial defect, and it avoids the risk of infection associated with the use of a BCL. It may be particularly useful for noncompliant or debilitated patients who are unreliable in carrying out conservative management methods, as well as for patients in whom lagophthalmos or exposure keratopathy contributes to defect formation daily) and doxycycline (20–100 mg twice daily) have each demonstrated benefits in patients with persistent epithelial defects. Overall, the Persistent Corneal Epithelial Defects (PCEDs) therapeutics market is further expected to increase by the major drivers, such as rising prevalent population, technological advancements, and upcoming therapies in the forecast period [2019–2030].

DelveInsight's "Corneal Epithelial Defect - Market Insights, Epidemiology, and Market Forecast-2030" report delivers an in-depth understanding of the Corneal Epithelial Defect , historical and forecasted epidemiology as well as the Corneal Epithelial Defect market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

The Corneal Epithelial Defect market report provides current treatment practices, emerging drugs, Corneal Epithelial Defect market share of the individual therapies, current and forecasted Corneal Epithelial Defect market Size from 2017 to 2030 segmented by seven major markets. The Report also covers current Corneal Epithelial Defect treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses the underlying potential of the market

The Corneal Epithelial Defect epidemiology division provide insights about historical and current Corneal Epithelial Defect patient pool and forecasted trend for every seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the DelveInsight report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

The Corneal Epithelial Defect market outlook of the report helps to build the detailed comprehension of the historic, current, and forecasted Corneal Epithelial Defect market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers and demand of better technology.

This segment gives a thorough detail of Corneal Epithelial Defect market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on annual cost of therapy, inclusion and exclusion criteria's, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

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