Terminal cancer body edema, protein is very low, not only affect treatment, more shorten life

Two years ago, the 72 - year - old old xu diagnosed with lung adenocarcinoma, because can't operation, through the chemotherapy, radiotherapy and anti-angiogenesis therapy, disease control for two years, but this year the CT liver metastases, he is very resistance to hospital, has been no standard treatment after liver metastasis, he gradually lower extremity edema, swelling has been spread up, gradually, The waist and upper limbs also began to appear swollen, at this time, the Don panicked and hurried to the hospital for treatment.

Why can tumour terminal stage appear puffiness? This is like around 1960, the country three years of natural disasters, people did not eat and drink, gradually appear bloated disease. Edema is due to malnutrition, the body's albumin is too low, that's what we call hypoproteinemia. Hypoproteinemia is shown on the test sheet as a decrease in total protein, albumin, or prealbumin.

Blood IS FLOWING INSIDE THE BLOOD VESSEL OF HUMAN BODY, 70% IS WATER IN THE BLOOD, there IS gap ACTUALLY BETWEEN the epithelial cells OF blood vessel wall, CAN THE WATER INSIDE THE BLOOD vessel leak out? Yes, but under normal circumstances, the pressure inside and outside the blood vessel is in dynamic balance, and this balance mainly depends on the colloid osmotic pressure, and the plasma albumin, globulin, fibrinogen formed osmotic pressure, is colloid osmotic pressure, colloid osmotic pressure can change the blood vessel inside and outside the fluid balance. Once the albumin is too low, the colloid osmotic pressure decreases, the vascular permeability increases, the water in the blood vessel will leak to the subcutaneous tissue outside the blood vessel through the vascular wall space, the excessive water in the subcutaneous tissue can not be absorbed, nor flow away, it will gather under the skin, and there will be swelling by a pit. This is called dystrophic edema.

Under normal circumstances, the plasma albumin of adults is about 35-55 g/L. Hypoalbuminemia can be diagnosed when the plasma albumin of patients is less than 35 g/L. Hypoalbuminemia is common in patients with advanced cancer and other severe diseases. The causes of hypoproteinemia mainly include four aspects:

1. Not eating enough

In advanced cancer patients, loss of appetite and anorexia caused by various reasons, malabsorption caused by gastrointestinal congestion, or digestive tract obstruction, difficulty in feeding, lead to the serious shortage of the three major nutrients that patients take in every day, without enough raw materials, unable to synthesize enough albumin.

2. No

The liver is the main organ for protein synthesis. Under normal conditions, approximately 0.2g/kg albumin is synthesized daily and delivered extrahepatic through the venous system. When the disease causes liver damage, it will lead to reduced liver protein synthesis capacity, reduced plasma protein synthesis, resulting in lower serum albumin levels. The vast majority of cancer patients with liver metastases will have varying degrees of hypoproteinemia, which is associated with decreased liver synthesis.

3. Lost and consumed too much

Nausea, vomiting, diarrhea and other adverse reactions cause loss of protein. In addition, tumor patients often have ascites and pleural effusion, and repeated puncture discharge will lead to massive loss of albumin. As a wasting disease, cancer patients have an accelerated catabolism of nutrients, including albumin, which is an excessive consumption of nutrients.

4. Abnormal distribution

In the advanced stage of malignant tumor, capillary endothelial cells will be destroyed, and then the systemic capillary permeability will increase, and the intravascular albumin will penetrate into the tissue space, resulting in hypoproteinemia.

How should terminal cancer patient appear whole body puffiness to do?

The puFFINESS THAT CAUSES TO LOW PROTEINEMIA, BASICALLY STRENGTHEN NUTRITION NAMELY, SUPPLEMENT HIGH GRADE PROTEIN FOOD (FISH SHRIMP protein etc.). For patients with poor appetite can be given artificial homogenate diet, whey protein total nutrition enteral nutrition agent. Severe hypoproteinemia with hydrothorax and edema can be directly injected albumin, and appropriate diuresis to reduce swelling. In general, 8g of human blood albumin is recommended for every 1L of ascites drained.