No Sleep For The Wicked

Introduction

The prevalence of insomnia in the general population ranges between 8-40%, depending on the definition used. While 20-30% of the general population has poor sleep (i.e., insomnia symptoms of difficulty initiating or maintaining sleep, early morning awakening, or non-restorative sleep at any given time), another 8-10% of the population suffers from chronic insomnia. Also, about 4% of the population use sleeping pills in a regular basis. However, the connection of insomnia with significant medical morbidity has not been examined until very recently. This has led to view insomnia and its associated mental and physical health complaints as a minor problem from a public health perspective.

A factor that may have contributed to this lack of firm association between insomnia and significant medical morbidity is the definitions used for this disorder and the lack of validated objective/biological markers. Sleep disorders were included for the first time in the Diagnostic and Statistical Manual of Mental Disorders (DSM)-III-R4 in 1987 and provided overall diagnostic criteria for “insomnia disorders” based on the subjective complaints of difficulty initiating or maintaining sleep or of non-restorative sleep, occurring at least 3 times a week for at least 1 month, and associated daytime functioning complaints. The DSM-IV-TR eliminated the overall diagnostic criteria for “insomnia disorders” as well as the frequency criterion, maintained the diagnoses of “primary insomnia”, “dysomnia NOS”, insomnia “related to another mental disorder”, “due to a general medical condition”, and introduced “substance-induced insomnia”. The DSM- has eliminated the different insomnia diagnoses in DSM-IV-TR to reintroduce overall diagnostic criteria for “insomnia disorder” with specification of comorbid mental and/or physical conditions, so that no causal attributions between insomnia and the physical/mental condition are made, and has extended the duration criterion from 1 month to 3 months. The latter change is an acknowledgement that chronicity is what differentiates insomnia as a disorder vs. insomnia symptoms, i.e., poor sleep due to underlying, identifiable physical, emotional, or drug-related factors.

The International Classification of Sleep Disorders (ICSD), and its revised form ICSD-R (1997), also defined insomnia based on subjective sleep and daytime functioning complaints but, in contrast, attempted to identify subtypes based on “intrinsic” factors such as etiology (i.e., “psychophysiological”), age of onset (i.e., “idiopathic insomnia”), degree of discrepancy between objective sleep findings and subjective perception of sleep (i.e., “sleep state misperception”) or “extrinsic” environmental factors such as “inadequate sleep hygiene”, “food-allergy” or “altitude insomnia”. However, these subtypes, even when refined in the ICSD- have not proven to be clinically useful and the reliability and validity of DSM and ICSD diagnoses is at best modest.

Although the objective sleep of insomniacs is different than that of normal sleepers, PSG variables are not required or recommended for the diagnosis of the disorder. In fact, PSG criteria have not proven to be useful in terms of differential diagnosis or severity assessment and are not currently used in clinical practice. The sleep laboratory is useful for the evaluation of patients with sleep-disordered breathing (SDB), the diagnosis of narcolepsy, and the differential diagnosis of idiopathic vs. psychogenic hypersomnia, as well as the study of the initial effectiveness, continued efficacy or tolerance, and potential withdrawal effects of a hypnotic drugs. The validity and clinical utility of sleep lab testing for diagnosing insomnia has been evaluated in large studies, that have shown that PSG measures such as latency to sleep onset, total sleep time, number of arousals and awakenings, sleep efficiency, or sleep stages, are not useful in the diagnosis or differential diagnosis including subtyping of insomnia, except to confirm or exclude other sleep pathologies when there is reasonable evidence from clinical history (e.g., SDB or periodic limb movements). The current consensus is, therefore, that PSG is not recommended for routine, differential diagnosis, or severity assessment of insomnia in clinical practice.

In this review paper, we present evidence that objective measures of sleep are useful in predicting the medical severity of insomnia (i.e., cardiometabolic and neurocognitive morbidity and mortality) and that should be considered in the new classification of insomnia.

Insomnia and the Stress System

In the last two decades, several models have been proposed to understand the etiology and pathophysiology of insomnia and most of them have emphasized the importance of the joint effect of stress and psychological factors in the pathogenesis of insomnia. The characteristic psychological profile of patients with insomnia, consisting of cognitive-emotional hyperarousal (i.e., obsessive, anxious, ruminative, and dysthymic personality traits) and emotion-oriented coping strategies, is thought to be present pre-morbidly and play a key role in the etiology of the disorder. Insomnia is associated with precipitating life events and cognitive-emotional arousal and is perceived by the patient as stressful on its own. Thus, insomnia should be expected to be associated with activation of the stress system.

Stress has been associated with the activation of the hypothalamic-pituitary-adrenal (HPA) and the sympatho-adrenal-medullary axes, whereas corticotropin-releasing hormone (CRH) and cortisol (products of the hypothalamus and adrenals, respectively), and catecholamines (products of the sympathetic system) are known to cause arousal and sleeplessness to humans and animals. On the other hand, sleep and particularly deep sleep appears to have an “anti-stress” effect as it is associated with an inhibitory effect on the stress system including its main two components, the HPA axis and the sympathetic system.

While the majority of early studies reported no difference between subjectively defined “poor sleepers” and controls in the levels of cortisol secretion, later studies found that 24-h urinary free cortisol, norepinephrine, and catecholamine metabolites levels were either increased in patients with insomnia with objective sleep disturbances as compared to controls or were correlated with PSG indices of sleep disturbance in insomnia patients. The few exceptions might be related to the fact that the objective sleep of patients with insomnia was very similar to that of controls or to lack of statistical power and controls not being carefully selected. In addition, it was shown that middle-aged healthy individuals were more vulnerable to the sleep disturbing effects of the stimulating hormones of the HPA axis, i.e., CRH, which may explain physiologically the increased prevalence of insomnia in older subjects. Furthermore, other studies have demonstrated that this type of insomnia is associated with increased nocturnal heart rate and impaired heart rate variability, increased overall oxygen consumption (VO2), a measure of whole-body metabolic rate, and increased pupil size, indicative of sympathetic system activation, but not in insomnia defined only on subjective measures.

Another paradox with patients with insomnia who typically complain that they are fatigued and sleepy during the day is that during the Multiple Sleep Latency Test (MSLT) they have either similar or increased daytime sleep latencies when compared to controls. In fact, several studies have shown that, within patients with insomnia, those with shorter objective sleep duration show longer sleep latencies in the MSLT and are more alert in vigilance tests. This is in contrast to normal individuals who after sleep deprivation experience significantly reduced sleep latencies on the MSLT and decreased alertness in vigilance tests, i.e., physiological sleepiness. Thus, long latencies in the MSLT may represent a reliable marker of physiological hyperarousal in insomnia patients.

Finally, evidence about the presence of central nervous system hyperarousal in insomnia comes from studies in human subjects using neuroimaging, and spectral, arousal, and event-related electroencephalography analyses as well as from studies on the neural circuitry of stress-induced insomnia in rats. Increased cortical arousal during sleep is present to a variable degree in all patients with insomnia and may explain why they perceive their sleep as wake and as non-restorative.

Insomnia and Cardiometabolic Morbidity

Until recently, chronic insomnia has not been linked firmly with significant medical morbidity, such as cardiovascular disease. Several surveys have shown a significant relationship between difficulty falling asleep or poor sleep with cardiometabolic outcomes such as hypertension and diabetes. For example, persistent complaints of difficulty initiating or maintaining sleep were associated with an increased risk of hypertension, acute myocardial infarction, and incident type 2 diabetes. However, these studies showed relatively small effect sizes and did not include a PSG evaluation so as to control for SDB or other sleep pathology. The findings of these early studies were dismissed as methodologically flawed by many clinicians and researchers alike. In fact, at least one report showed a reduced mortality rate for those individuals complaining of sleep difficulties after 6 years of follow-up.

Given the well-established association of hypercortisolemia with significant medical morbidity, (i.e., hypertension, diabetes, metabolic syndrome, osteoporosis, and others), we hypothesized that insomnia with objective short sleep duration is associated with significant cardiometabolic morbidity and mortality. A series of recent epidemiological studies from the Penn State Adult Cohort, that used in-lab PSG, have shown that insomnia with objective short sleep duration is associated with a high risk of hypertension, diabetes, and mortality. For example, compared to normal sleepers who slept ≥ 6h per night, the highest odds of hypertension or diabetes was in patients with insomnia who slept ≤5h (OR = 5.1 and OR = 2.95, respectively) and the second highest in patients with insomnia who slept 5-6 h (OR = 3.5 and OR = 2.07, respectively), while patients with insomnia who slept ≥ 6h were not at significantly increased risk of hypertension or diabetes (OR = 1.3 and OR = 1.1, respectively). Recent longitudinal data from the same cohort has shown that patients with insomnia who slept < 6h were at a significantly higher risk of incident hypertension (OR = 3.75), suggesting that insomnia precedes the onset of hypertension. Interestingly, in a recent longitudinal study we found that non-obese chronic insomniacs, despite sleeping objectively shorter than controls or poor sleepers, did not have a significantly increased risk of incident obesity; in fact, they were less likely to become obese than controls or poor sleepers. These data indicate that insomnia with objective short sleep duration may be linked to medical morbidity such as hypertension and diabetes through mechanisms other than weight gain and obesity (i.e., activation of the stress system and inflammation process). Furthermore, other longitudinal research showed that mortality risk in men was significantly increased in patients with insomnia who slept < 6 h compared to normal sleepers (OR = 4.00), and that there was a marginally significant trend toward higher mortality from insomnia with short sleep duration in men with diabetes or hypertension (OR = 7.17) than in those without these comorbid conditions (OR = 1.45). Thus, the impact of insomnia with short sleep duration was much stronger in those with diabetes and hypertension at baseline versus those who were healthy. In women, mortality was not associated with insomnia with short sleep duration, most likely related to the fact that women were followed-up for a shorter time period.

Consistent with the findings of these population-based studies, other recent studies have shown higher nighttime systolic blood pressure and reduced day-to-night systolic blood pressure dipping, impaired heart rate variability, lower cardiac pre-ejection period, and poorer indices of glucose metabolism in patients with insomnia. Cumulatively, these data suggest that objective short sleep duration may predict the medical severity of chronic insomnia.

Insomnia and Neurocognitive Morbidity

Patients with insomnia typically complain of difficulty concentrating, memory problems, and difficulty focusing attention. However, studies using objective neuropsychological testing have produced inconsistent findings. This has led some researchers to question the existence of true cognitive impairments in insomnia and attribute the daytime complaints to excessive attention to the expected consequences of poor sleep.

The role of objective sleep measures in the association of insomnia with cognitive impairment has been addressed in a recent study from the Penn State Adult Cohort. This study showed that patients with insomnia, based solely on a subjective complaint, did not differ significantly from controls on either PSG variables or neurocognitive performance. However, significant interactions between insomnia and objective short sleep duration (i.e., < 6h) on specific neurocognitive tests were found. Specifically, patients with insomnia with objective short sleep duration showed poorer neuropsychological performance on tests of processing speed, switching attention, and number of short-term visual memory errors and omissions compared to control groups with normal or short sleep duration. In contrast, patients with insomnia with normal sleep duration group showed no significant deficits when compared to controls. Based on these findings, it seems that insomnia with objective short sleep duration is associated with deficits in switching attention, a key component of the “executive control of attention”. Importantly, the presence of a group of good sleepers with short sleep duration allowed to demonstrate that deficits in executive attention were associated with underlying physiological hyperarousal, a characteristic of chronic insomnia, rather than to short sleep per se. Another recent study by Edinger et al, examined the association between physiological hyperarousal, as measured by the MSLT, and response accuracy on reaction time tasks among individuals with primary insomnia as compared to well-screened normal sleepers. Interestingly, the authors found that individuals with MSLT mean onset latency > 8 min showed lower nighttime sleep efficiencies and increased wake after sleep onset, suggesting 24-h physiological hyperarousal particularly in the primary insomnia group. Importantly, they found a significant interaction between insomnia and increased MSLT mean onset latency so that individuals with primary insomnia and with MSLT mean onset latency > 8 min showed greater error rates in switching attention tasks than normal sleepers with MSLT mean onset latency > 8 min, who showed no significant deficits. The authors concluded that physiological hyperarousal in insomnia may lead to increased daytime alertness yet dispose these individuals to higher error rates on tasks of switching attention, a finding consistent with those of a study by Fernandez-Mendoza et al., in which physiological hyperarousal was ascertained by objective short sleep duration.

A recent meta-analysis has shown that individuals with insomnia exhibit performance impairments of small to moderate magnitude in several cognitive functions, including working memory, episodic memory, and some aspects of executive functioning. However, an important factor that has been neglected in meta-analytic research of the neurocognitive literature is the role of the degree of objective sleep disturbance in this association. As we have recently reviewed, most studies have shown that cognitive performance is impaired in patients with insomnia with objective sleep disturbances or that it correlates with objective markers of sleep disturbance in patients with insomnia, whereas those studies in which performance was not significantly impaired established insomnia diagnoses using solely subjective criteria.

Cumulatively, the data from these studies indicate that objective short sleep duration may predict its effect on cognitive functions. Future studies should examine whether insomnia with objective short sleep duration may be a premorbid risk factor for mild cognitive impairment (MCI) and dementia.

Insomnia and Psychiatric Morbidity

Many studies have established that insomnia is highly comorbid with psychiatric disorders and is a risk factor for the development of depression, anxiety, and suicide. However, the mechanisms by which insomnia precedes the development of psychiatric disorders, e.g., depression, are unknown. In a recent study from the Penn State Adult Cohort, insomnia with objective short sleep duration was associated with a psychological profile consistent with depressed mood, fatigue, concerns about health and physical functioning, somatically focused anxiety, and poor health status, which is typical of medical outpatients. In contrast, insomnia with normal sleep duration was associated with sleep misperception (i.e., the underestimation of time asleep and overestimation of time awake during the night) and a psychological profile consistent with depressed mood, rumination, anxiety, intrusive thoughts, and poor coping resources. These data have led us to suggest that both insomnia subtypes are associated with (or are at risk of developing) psychiatric disorders but that different pathophysiological mechanisms may account for such an association. For example, it is possible that biological mechanisms, i.e., hyperactivity of the HPA axis, may play a role in the development of depression in insomniacs with objective short sleep duration, while psychological mechanisms, i.e., poor coping resources and ruminative traits, may play such a role in insomniacs with normal sleep duration. However, these hypotheses need yet to be tested.

Natural History of Insomnia: Chronic Insomnia vs. Poor Sleep

As mentioned in the introduction, about 20% of the general population has poor sleep (i.e., insomnia symptoms at any given time) and about another 10% has chronic insomnia. Natural history studies have shown that chronic insomnia is a highly persistent condition, whereas the course of poor sleep is more variable and has a higher remission rate. This suggests that insomnia is a disorder while poor sleep is a symptom of underlying mental and physical health problems. Furthermore, objective short sleep duration has been shown to be a risk factor for poor sleep evolving into the more severe form of chronic insomnia as well as of chronic insomnia becoming persistent. These latter findings suggest that objective short sleep duration may be a biologic marker of genetic predisposition to chronic insomnia and of the severity and chronicity of the disorder

Conclusion

As a result of the above-reviewed literature we have suggested two phenotypes of chronic insomnia. The first phenotype is primarily associated with physiological hyperarousal (i.e., short sleep duration and activation of both limbs of the stress system), significant medical sequelae (e.g., hypertension, diabetes, cognitive impairment, increased mortality), and a persistent course. The second phenotype is associated with cognitive-emotional and cortical arousal, but not with physiological hyperarousal (i.e., normal sleep duration and normal activity of the stress system) or significant medical sequelae, and is more likely to remit over time. Furthermore, the first phenotype is associated with a psychological profile typical of medical outpatients, whereas the second phenotype is associated with sleep misperception, anxious-ruminative traits, and poor coping resources. Table 1 summarizes the findings of key studies, while Figure 1 depicts a heuristic model of the underlying pathophysiological mechanisms and clinical characteristics of the two insomnia phenotypes.