Top 10 Knee Injection Clinics in USA
Knee Injection Clinics Near You in USA

Top 10 Knee Injection Clinics in USA
Chronic knee pain affects millions of Americans, making everyday tasks difficult and reducing quality of life. Whether caused by arthritis, injury, or overuse, managing knee pain effectively is crucial. One of the most effective non-surgical treatments available today is the knee injection.
From corticosteroids to regenerative therapies like PRP and hyaluronic acid, knee injections can significantly reduce inflammation, improve mobility, and delay or prevent surgery. In this guide, we highlight the top 10 knee injection clinics across the United States that deliver cutting-edge treatments and patient-centered care—starting with the highly rated Menz Clinic in Orlando.
1. Menz Clinic – Orlando, Florida
When it comes to knee injection treatments, Menz Clinic is leading the way in innovation and patient outcomes. Based in Orlando, this clinic is renowned for its expertise in regenerative therapies and personalized pain management strategies.
Why Choose Menz Clinic:
- Specializes in PRP and hyaluronic acid knee injections
- Non-surgical solutions for arthritis, meniscus tears, and sports injuries
- Uses image-guided techniques for precision and effectiveness
- Trusted by both athletes and general patients alike
With a focus on lasting relief and joint function restoration, Menz Clinic is a top destination for anyone considering a knee injection.
Location: Orlando, Florida
Website: menzclinic.com
2. Cleveland Clinic – Cleveland, Ohio
Recognized nationwide for orthopedic care, Cleveland Clinic offers a full range of knee injection therapies tailored to various joint conditions.
Highlights:
- Corticosteroid and hyaluronic acid knee injections
- Cutting-edge diagnostic tools and image-guided injections
- Comprehensive pain management programs
Cleveland Clinic's evidence-based approach ensures effective and safe treatment for patients experiencing chronic knee discomfort.
3. Hospital for Special Surgery (HSS) – New York, NY
HSS is globally known for orthopedic excellence. Their customized knee injection programs are backed by years of research and clinical success.
Features:
- Expertise in treating osteoarthritis and cartilage damage
- Gel and PRP knee injections
- Combined treatment plans including physical therapy
Their advanced techniques make HSS a top pick for patients who want holistic care and measurable outcomes.
4. Mayo Clinic – Rochester, Minnesota
Mayo Clinic provides top-tier care in multiple specialties, including orthopedics. Patients from across the country come here for expert-guided knee injection treatments.
Services Offered:
- Cortisone and gel-based knee injections
- Diagnostic imaging for precise placement
- Innovative regenerative solutions available
Mayo’s patient-focused approach and clinical innovation make it a standout facility for knee pain treatment.
5. Rush University Medical Center – Chicago, Illinois
Rush University Medical Center is another leader in orthopedic and sports medicine. Their team provides targeted knee injection therapies with a focus on improving quality of life.
Notable Benefits:
- Ultrasound-guided knee injections for pinpoint accuracy
- Treatment plans for both acute and chronic knee conditions
- Supportive rehabilitation services post-injection
Rush delivers a blend of compassion, innovation, and excellent clinical outcomes.
6. Johns Hopkins Orthopedics – Baltimore, Maryland
Johns Hopkins is renowned for its academic and clinical excellence. Their orthopedic division offers various knee injection options suited to different patient needs.
Available Treatments:
- Corticosteroid, PRP, and visco supplementation knee injections
- Tailored treatment for arthritis and soft tissue damage
- Advanced imaging to enhance injection accuracy
Patients trust Johns Hopkins for its balanced mix of innovation and top-tier care.
7. Kerlan-Jobe Institute – Los Angeles, California
A go-to destination for professional athletes, Kerlan-Jobe Institute is also highly recommended for anyone seeking high-performance knee injection therapies.
Services:
- PRP and stem cell knee injections
- Sports-specific rehabilitation programs
- Minimally invasive alternatives to surgery
Kerlan-Jobe is ideal for individuals wanting to return to peak physical activity without invasive procedures.
8. OrthoCarolina – Charlotte, North Carolina
OrthoCarolina is known for delivering comprehensive orthopedic services across the Southeast. They offer effective and personalized knee injection solutions for all ages.
Advantages:
- Fast appointments and same-day diagnostics
- Hyaluronic acid and corticosteroid knee injections
- Therapy plans that include exercise and mobility training
The clinic emphasizes reducing downtime and enhancing long-term joint health.
9. Texas Orthopedics – Austin, Texas
Serving Central Texas, Texas Orthopedics provides expert knee injection treatments with a team of board-certified specialists in joint care.
What to Expect:
- PRP and cortisone knee injections
- Advanced imaging for safe and precise applications
- On-site physical therapy for improved recovery
With a focus on patient education and comfort, Texas Orthopedics is a trusted name in the region.
10. Andrews Sports Medicine – Birmingham, Alabama
Andrews Sports Medicine is a top-tier clinic dedicated to orthopedic excellence. Known for treating high-performance athletes, their knee injection therapies are also available to the general public.
What They Provide:
- PRP, stem cell, and gel-based knee injections
- Comprehensive evaluations and digital imaging
- Recovery programs customized to each patient's goals
If you're looking for cutting-edge treatment in a supportive environment, Andrews Sports Medicine is an excellent choice.
Most Common Types of Knee Injections
When evaluating your treatment options, understanding the different types of knee injections can help you make an informed choice:
- Corticosteroid Injections – Used to reduce inflammation and swelling quickly.
- Hyaluronic Acid (Gel Injections) – Helps lubricate the joint for smoother movement.
- Platelet-Rich Plasma (PRP) – Uses your body’s own platelets to promote healing.
- Stem Cell Therapy – A regenerative option for those with more advanced degeneration.
Each of the clinics listed above offers one or more of these treatments to relieve pain and improve joint function.
Key Benefits of Knee Injections
Choosing a knee injection as your treatment path has many advantages:
- Non-surgical and minimally invasive
- Fast relief with little to no downtime
- Customizable to your condition and severity
- Often covered by insurance
- Can delay or eliminate the need for surgery
If you’re experiencing persistent knee pain that hasn’t improved with physical therapy or medication, a knee injection could be the right next step.
When Is the Right Time to Consider a Knee Injection?
You should consider a knee injection if:
- You have arthritis or degenerative joint disease
- Your knee is swollen, stiff, or painful regularly
- Physical activity causes joint pain or limited motion
- You’ve exhausted over-the-counter or conservative treatments
Early intervention can often prevent further joint deterioration and improve mobility.
Final Thoughts
Knee pain doesn’t have to hold you back. With so many proven options available, a knee injection could be the solution that restores your mobility and improves your quality of life.
Start your healing journey with one of the best, Menz Clinic in Orlando, the leader in knee injection therapy. From regenerative treatments to precise diagnostics, Menz Clinic offers personalized care with powerful results.
Whether you're an athlete, a weekend warrior, or someone seeking relief from arthritis, the clinics listed in this guide offer the most effective knee injection treatments in the USA. Schedule your consultation today and take the first step toward a pain-free future.



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