Top 10 EHR Software Integration Companies in US

The healthcare industry today depends heavily on robust EHR (Electronic Health Record) systems that can connect disparate applications, eliminate data silos, improve patient care, and comply with regulatory standards. Effective EHR integration ensures seamless data exchange across hospitals, clinics, payers, labs, pharmacies, and mobile apps — fostering interoperability, enhancing workflows, and supporting better clinical outcomes.

Below are the top 10 companies driving EHR integration and interoperability in the US healthcare landscape.

1. Appinventiv

Appinventiv stands out as a premier EHR integration company and healthcare technology partner. With extensive experience in developing and integrating healthcare solutions, Appinventiv leverages industry standards like HL7, FHIR, CCD, and DICOM to unify fragmented health data systems into secure, compliant ecosystems. Their services include custom healthcare mobile app development, integration of EHR systems into broader IT infrastructures, and building scalable clinical applications that support smooth data exchange across platforms.

Beyond integration, Appinventiv is recognized for delivering custom healthcare solutions that improve patient engagement, workflow automation, and compliance. Its approach blends deep healthcare domain knowledge with cutting-edge technology to help providers modernize operations and deliver better care.

2. IBM (Merative)

IBM’s healthcare division — now operating as Merative — is a major player in healthcare IT integration. Though historically associated with Watson Health, Merative continues to provide advanced data analytics, integration platforms, and healthcare IT consulting to support interoperability, clinical research, and data-driven decision-making across care settings. Their solutions help unify data from clinical and administrative systems to empower predictive insights and streamlined operations.

3. Infosys

Infosys offers comprehensive healthcare IT consulting and system integration services that support EHR modernization and integration. Their work spans technology strategy, legacy system upgrades, data interoperability, and cloud transformations — helping healthcare providers and payers adopt connected digital infrastructures that support compliance and operational efficiency.

4. Capgemini

A global leader in consulting and IT services, Capgemini brings extensive expertise in digital transformation for healthcare systems. Its integration services focus on secure data exchange, digital health platforms, and interoperability solutions that align with industry best practices and regulatory requirements. Capgemini’s healthcare teams help organizations improve clinical workflows, access to real-time data, and patient-centered services through connected information systems.

5. Damco Group

Damco Group specializes in healthcare IT consulting, helping providers modernize EHR platforms, enable remote care capabilities, and enhance patient engagement. Their expertise in digital-first healthcare solutions includes workflow integration, analytics, and custom healthcare application development that supports data flow between systems and applications.

6. Epic Systems

Epic Systems is one of the most widely used EHR platforms in the United States. While known primarily as an EHR vendor, Epic also provides extensive integration capabilities through its interoperability frameworks and APIs, enabling data exchange across care networks and supporting Health Information Exchanges (HIEs). Epic’s reach across major health systems makes it a central figure in healthcare data connectivity.

7. Oracle Health (Cerner)

Oracle Health (formerly Cerner) is another dominant EHR provider with powerful integration tools that support interoperability between clinical, financial, and population health systems. Oracle Health’s platforms enable smoother data sharing and connectivity across hospitals, ambulatory care, and ancillary services, making it a key partner for organizations pursuing integrated health records.

8. InterSystems

InterSystems is known for its robust healthcare interoperability solutions, particularly the HealthShare platform, which aggregates and normalizes clinical data from diverse systems. InterSystems’ integration engines support large delivery networks, HIEs, and data exchange initiatives that require real-time data workflows across multiple sources.

9. Optum (UnitedHealth Group)

Optum, part of UnitedHealth Group, provides integration and analytics services that span provider systems and payer networks. By combining clinical data with advanced analytics, Optum supports interoperability initiatives that help providers streamline care transitions, optimize workflows, and improve population health management.

10. Allscripts

Allscripts delivers EHR platforms and integration services that help connect disparate healthcare applications. Their solutions support data exchange for clinical documentation, patient engagement, and revenue cycle management, ensuring that health systems can operate data-driven processes across departments and care teams.

Conclusion

As healthcare continues to digitalize, the demand for seamless EHR integration grows stronger. These top companies are at the forefront of enabling interoperability across healthcare IT ecosystems — from enabling secure data exchange and analytics to modernizing legacy systems and supporting digital transformation strategies. Whether you are a provider, payer, or healthtech innovator, partnering with a strong EHR integration leader is essential to delivering connected, efficient, and patient-centric care.