United States Organ Preservation Market to Experience Strong Growth Fueled by Rising Transplant Procedures and Advances in Preservation Technologies

The Global Organ Preservation Market is projected to witness strong growth in the coming years, supported by the increasing number of organ transplantation procedures, technological advancements in preservation methods, and rising public awareness around organ donation. The global organ preservation market, valued at USD 0.24 billion in 2024, is expected to reach USD 0.36 billion by 2030, expanding at a compound annual growth rate (CAGR) of 6.8% during the forecast period.

Organ transplantation remains the gold standard treatment for end-stage organ failure, and as the number of transplant candidates continues to rise worldwide, the demand for efficient organ preservation solutions is surging. Effective preservation methods are essential to maintain organ viability and functionality between procurement and transplantation — a critical determinant of patient survival and transplant success rates.

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Growing Burden of Chronic Diseases and Rising Transplant Volume

The rising prevalence of chronic diseases such as diabetes, cardiovascular disorders, chronic kidney disease, and liver cirrhosis has led to an increasing number of patients requiring organ transplants. According to global health statistics, more than 150,000 solid organ transplants are performed each year, with kidneys, livers, hearts, and lungs being the most commonly transplanted organs.

However, a significant gap remains between organ availability and demand, emphasizing the need for better organ preservation techniques to minimize wastage and improve outcomes. Advances in preservation technologies — including dynamic perfusion and temperature-controlled storage — are addressing these challenges by extending the viable preservation window and improving transplant success rates.

Hospitals and transplant centers are increasingly adopting machine perfusion systems that replicate physiological conditions, helping to reduce ischemic injury and enhance organ quality, especially for marginal or donor-after-circulatory-death (DCD) organs.

Technological Advancements Transforming Organ Preservation

Technological innovation has been a driving force in improving organ preservation efficiency. Hypothermic machine perfusion (HMP) and normothermic machine perfusion (NMP) have emerged as game-changing techniques compared to traditional static cold storage. These methods provide continuous oxygenation and nutrient supply to the organ, reducing tissue damage during storage.

• Hypothermic machine perfusion (HMP): This method is increasingly used for kidney preservation, improving post-transplant outcomes and extending organ viability for up to 24–36 hours.

• Normothermic machine perfusion (NMP): Gaining traction in liver and heart preservation, NMP maintains organs at near-body temperature, allowing real-time assessment of organ function prior to transplantation.

Innovations such as portable organ transport devices, AI-assisted perfusion monitoring, and next-generation preservation solutions with antioxidant and anti-inflammatory agents are also shaping the market landscape. These advances not only enhance organ survival rates but also increase the utilization of donor organs that might otherwise be discarded.

Cold Storage Solutions Remain Dominant but Perfusion Gains Ground

Cold storage continues to be the most widely used preservation method due to its simplicity, cost-effectiveness, and reliability for short-term preservation. Widely used preservation solutions such as University of Wisconsin (UW) solution, Custodiol HTK, and Celsior solution remain standards in most transplant centers worldwide.

However, the market is witnessing a steady transition toward dynamic preservation systems — especially in developed healthcare markets — driven by growing evidence of improved clinical outcomes. Manufacturers are increasingly investing in developing hybrid systems that combine cold storage stability with perfusion technology to optimize organ quality and minimize ischemic injury.

Key Market Segments: Solutions, Techniques, and Organs

The organ preservation market is segmented by solution type, preservation technique, organ type, and end-user.

• By Solution: The UW solution dominates the market due to its proven efficacy in preserving liver and kidney grafts. Custodiol HTK and Perfadex solutions are also gaining traction, particularly in heart and lung preservation.

• By Technique: Static cold storage (SCS) remains the most common method; however, machine perfusion — both hypothermic and normothermic — is growing rapidly as hospitals adopt advanced technologies.

• By Organ Type: The kidney accounts for the largest market share, followed by liver and heart transplants. Demand for lung preservation solutions is also increasing, supported by research into ex vivo lung perfusion (EVLP).

• By End-User: Transplant centers, hospitals, and organ procurement organizations (OPOs) represent the major end-users, with OPOs playing a key role in logistics and storage optimization.

Rising Focus on Organ Donation Awareness and Infrastructure Development

The global emphasis on organ donation awareness and infrastructure development has significantly benefited the organ preservation industry. Public-private partnerships, educational campaigns, and policy initiatives are enhancing organ donation rates and strengthening national transplant networks.

Countries across North America and Europe have implemented opt-out donation systems and digital donor registries to streamline donor identification and organ allocation. In parallel, advancements in logistics — including temperature-controlled transport and GPS-tracked preservation containers — are ensuring safer, faster, and more reliable delivery of organs between donor and recipient sites.

The collaboration between organ procurement organizations (OPOs), biotech innovators, and medical device manufacturers is further driving the standardization of preservation protocols and the adoption of best practices across the transplant ecosystem.

Regional Insights and Competitive Landscape

North America continues to lead the global organ preservation market, supported by a high transplant rate, strong clinical infrastructure, and favorable reimbursement policies. Europe follows closely, driven by government-led organ donation programs and research funding. Meanwhile, the Asia Pacific region is emerging as a high-growth market, propelled by rising healthcare investment, expanding transplant programs, and increasing awareness around organ donation.

Leading players operating in the global organ preservation market include XVIVO Perfusion AB (Sweden), Paragonix Technologies (US), Bridge to Life Ltd. (US), TransMedics Group Inc. (US), OrganOx Limited (UK), and Dr. Franz Köhler Chemie GmbH (Germany). These companies are focusing on technological innovation, strategic collaborations, and expansion into emerging markets to strengthen their presence.

Recent developments — such as TransMedics’ Organ Care System (OCS) for heart and lung perfusion, and Paragonix’s SherpaPak cardiac transport system — are redefining preservation standards and improving transplant logistics.

Future Outlook: Advancing Toward Precision Preservation

The organ preservation industry is poised for a transformative decade marked by technological integration, regulatory support, and precision-based preservation approaches. Artificial intelligence, IoT-enabled monitoring, and biocompatible preservation solutions are expected to revolutionize how organs are maintained and evaluated before transplantation.

As organ transplantation continues to evolve into a more data-driven, technology-enabled discipline, the United States Organ Preservation Market is set to play a pivotal role in advancing global standards of care. Strategic investment in R&D, cross-border partnerships, and patient-centric innovations will remain key drivers of sustainable growth through 2030.