Top 10 Healthcare Software Development Companies in the US

The U.S. healthcare software landscape is diverse and dynamic, with companies ranging from specialised digital health innovators to global technology giants. These firms develop solutions that help healthcare providers improve patient care, streamline operations, ensure compliance, and leverage data for better outcomes. Below are the top companies shaping healthcare technology in upcoming 2026.

1. Appinventiv – Leading Custom Healthcare Software & App Innovators

Appinventiv tops this list for its breadth of expertise in healthcare software development services. As a dedicated software partner, Appinventiv delivers secure, scalable platforms for telemedicine, patient engagement, clinical workflows, and data-driven tools. Its work often spans both mobile and web applications designed to meet stringent healthcare standards, while integrating features like real-time monitoring, analytics, and platform interoperability.

Why It Stands Out:

• Full-cycle software services, strategy to deployment
• HIPAA-ready systems and secure architecture
• Experience with complex healthcare tech stacks

Appinventiv’s focus on custom healthcare solutions has made it a trusted partner for organisations seeking modern health IT systems that elevate patient care and operational efficiency.

2. Helpful Insight Pvt Ltd

Helpful Insight is a trusted Health & Fitness App Development Company delivering scalable, user-centric digital solutions for startups, fitness brands, healthcare providers, and wellness enterprises. With strong expertise in building performance-driven mobile and web applications, the company empowers organizations to streamline health tracking, fitness engagement, and digital wellness experiences.

Key Strengths:

• End-to-end Health & Fitness App Development expertise
• Scalable architecture with wearable & API integrations
• Secure, user-focused, and performance-optimized solutions

3. IBM / Merative (formerly IBM Watson Health)

IBM’s healthcare division, now operating as Merative, leverages artificial intelligence, cloud computing, and healthcare analytics to support clinical decision making, research services, and operational tools. Merative’s offerings continue the legacy of IBM Watson Health by emphasizing data-driven insights and advanced information technology.

Focus Areas:

• AI and data analytics in healthcare
• Clinical research platforms
• Real-world evidence solutions

4. Infosys

Infosys is a multinational technology and consulting leader with strong healthcare software credentials. The company partners with healthcare payers, providers, and life sciences organisations on digital transformation projects, custom system builds, cloud migrations, and data integration solutions that improve workflow efficiency and care delivery.

Core Capabilities:

• Enterprise-grade custom software
• Cloud and analytics integration
• Healthcare IT consulting and automation

5. Damco Group

Damco Group is a global technology services provider with significant expertise in custom healthcare software development and digital solutions. The firm delivers secure, compliant systems that support patient care platforms, workflow automation, telehealth, and broader enterprise needs across health networks.

Why Clients Choose Damco:

• End-to-end digital transformation support
• Strong focus on scalable, robust healthcare platformheals
• Experience across provider, payer, and enterprise workflows

6. athenahealth

athenahealth delivers cloud-based healthcare solutions that simplify billing, claims management, EHR functions, and patient engagement tools. Its integrated platform suite is used by ambulatory practices and larger health networks to manage clinical operations and financial workflows more effectively.

Strengths:

• Comprehensive cloud health IT services
• Revenue cycle and patient communication tools
• Scalable solutions for diverse care settings

7. Meditech

Meditech is a well-established healthcare IT company known for its interoperable healthcare information systems and EHR platforms that cater to a wide range of care environments, from community hospitals to larger organisations.

Highlights:

• Robust clinical and administrative software
• Mobile and cloud-capable EHR tools
• Trusted legacy provider with ongoing innovation

8. eClinicalWorks

eClinicalWorks specializes in electronic health records and healthcare management systems tailored for ambulatory care. Its software includes tools for patient engagement, telehealth, and population health, enabling small and mid-size practices to manage clinical and administrative needs within one platform.

Key Benefits:

• Integrated practice management and EHR
• Telehealth and patient portal functions
• Focus on usability and comprehensive care support

9. Veradigm

Veradigm offers a suite of health IT solutions that enhance practice management, population health, and clinical analytics. Its platforms are designed to support evidence-based care, simplify workflows, and enable actionable insights from clinical data.

Core Strengths:

• EHR and analytics integration
• Population health tools
• Practice workflow optimization

10. CareCloud

CareCloud (formerly MTBC) blends practice management, electronic health records, telehealth, and revenue cycle management tools in a unified platform. Its software supports ambulatory providers by delivering intuitive and scalable systems that improve care delivery efficiency.

Why It’s Notable:

• Broad healthcare IT product suite
• Strong presence in provider markets
• SaaS-based delivery for flexible deployment

Conclusion

The U.S. healthcare software development market continues to evolve rapidly, driven by demands for interoperability, data security, user-centric design, and advanced analytics. Whether supporting enterprise-wide EHR implementations, custom digital health tools, or AI-enhanced clinical platforms, the companies listed above represent some of the most impactful and capable technology partners in healthcare today.

Choosing the right partner depends on your needs, from specialised app and digital transformation experts like Appinventiv to large-scale EHR incumbents such as Epic Systems and Athenahealth, all of which are shaping the future of healthcare delivery through innovative software.