Nucleic Acid Isolation and Purification Market: Preparing Clean DNA and RNA for Diagnostic Testing

Rising demand for molecular diagnostics, genetic testing, and biomedical research is driving growth in the nucleic acid isolation and purification market. Increased adoption of PCR, next-generation sequencing, and personalized medicine boosts usage. Technological advancements enabling faster, automated, and high-purity extraction improve laboratory efficiency. According to IMARC Group's latest research publication, The global nucleic acid isolation and purification market size was valued at USD 5.7 Billion in 2024. Looking forward, IMARC Group estimates the market to reach USD 10.5 Billion by 2033, exhibiting a CAGR of 7.1% during 2025-2033.

How AI is Reshaping the Future of Nucleic Acid Isolation and Purification Market

• Automated Protocol Optimization: AI can adjust the extraction protocols to obtain improved DNA/RNA yield and purity, while reducing hands-on time by up to 30% in high-throughput laboratories.
• Real-Time Quality Control: By monitoring extraction quality throughout the processing, machine learning can detect poor quality samples earlier and avoid the costs of sequencing or PCR downstream.
• Predictive maintenance systems monitor and analyze the performance patterns of specific equipment and use AI algorithms to predict problems before they occur, reducing downtime and avoiding sample processing delays in clinical and research laboratories.

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Nucleic Acid Isolation and Purification Industry Overview:

North America has good infrastructure and high research funding, accounting for 42.6% of the global genomics market. The National Institutes of Health spent USD 12,445 million on genomics research funding, driving extraction technology development. Thermo Fisher Scientific announced a USD 2 Billion investment into U.S. biotech manufacturing and research expansion. QIAGEN announced its 1,000th placement of an EZ2 Connect automated instrument. More than 5500 EZ series systems in use worldwide automate purification workflows in clinical and research laboratories for faster, more reproducible sample processing times.

Nucleic Acid Isolation and Purification Market Trends & Drivers:

The demand for automation systems is increasing due to the introduction of molecular diagnostics and personalized medicine. In Canada, 11% of adults have used DTC genetic testing kits and 60% said they were open to using genetic testing kits. Automated systems can remove up to 86% of manual process steps. The World Health Organization reported over 52,586 SARS-CoV-2 samples tested from 78 countries during the week of 5-11 May alone, revealing how the use of nucleic acid testing is critical to infectious disease surveillance and public health monitoring.

Because of the need for high-purity nucleic acids for gene therapy and biopharmaceuticals, BiOptic Inc. has consolidated the OpenGene operations and increased the production capacity by over 50% to serve the precision medicine and genetic testing market. Beckman Coulter and Illumina have provided cancer research solutions with fewer touchpoints and a shorter time. Magnetic bead automation provides 20% lower cycle time and reduced risk of cross-contamination with sealed-tip architectures in pharmaceutical quality control labs.

Government actions and infrastructure investments also drive the market: The Luxembourg Institute of Health received EUR 20 Million for its participation in the Genome of Europe project, a EUR 45 Million investment across 26 countries to create European reference genomes. Since GLOBOCAN estimates breast cancer cases in MENA are expected to grow from 118,200 to 219,000 by 2050 increasing the need for molecular diagnostics, Seegene and Springer Nature jointly initiated the Nature Awards MDx Impact Grants with a total fund of USD 600,000 for developing PCR assays in 47 countries.

Leading Companies Operating in the Global Nucleic Acid Isolation and Purification Industry:

• Abcam plc
• Agilent Technologies Inc.
• Bio-Rad Laboratories Inc.
• Illumina Inc.
• Macherey-Nagel Gmbh & Co. Kg
• New England Biolabs
• Norgen Biotek Corp.
• Omega Bio-Tek Inc.
• Promega Corporation
• Qiagen
• Roche Molecular Systems Inc. (F. Hoffmann-La Roche AG)
• Takara Bio Inc. (Takara Holdings Inc.)
• Thermo Fisher Scientific Inc.

Nucleic Acid Isolation and Purification Market Report Segmentation:

By Product:

• •Kits and Reagents
• Instruments

Kits and reagents represent the largest class, holding 75.9% of the market, as they provide ready-to-use, cost-effective solutions for isolating high-quality nucleic acids across diverse applications.

By Type:

• Plasmid DNA Isolation and Purification
• Total RNA Isolation and Purification
• Circulating Nucleic Acid Isolation and Purification
• Genomic DNA Isolation and Purification
• Messenger RNA Isolation and Purification
• microRNA Isolation and Purification
• PCR Cleanup
• Others

Plasmid DNA isolation and purification holds 20.4% market share owing to essential applications in biotechnology, gene therapy, recombinant protein production, and synthetic biology.

By Method:

• Column-Based Isolation and Purification
• Magnetic Bead-Based Isolation and Purification
• Reagent-Based Isolation and Purification
• Others

Column-based isolation and purification leads with 33.6% market share due to efficiency, simplicity, scalability, and reliable performance across research and clinical laboratories.

By End User:

• Hospitals and Diagnostic Centers
• Academic and Government Research Institutes
• Pharmaceutical and Biotechnology Companies
• Contract Research Organizations
• Others

Hospitals and diagnostic centers dominate with 32.1% market share as molecular diagnostics adoption increases for accurate disease diagnosis and personalized treatment strategies.

Regional Insights:

• North America (United States, Canada)
• Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, Others)
• Europe (Germany, France, United Kingdom, Italy, Spain, Russia, Others)
• Latin America (Brazil, Mexico, Others)
• Middle East and Africa

North America exhibits clear dominance in the nucleic acid isolation and purification market, holding over 42.6% market share due to advanced healthcare infrastructure and strong biotechnology presence.

Recent News and Developments in Nucleic Acid Isolation and Purification Market

• In June 2025, Xpedite Diagnostics partnered with Stratech Ltd to distribute SwiftX rapid nucleic acid extraction kits throughout the United Kingdom and Republic of Ireland. This added local delivery, stock holdings at planned distribution locations, expert support, and avoidance of customs and international delivery burdens for United Kingdom and Republic of Ireland laboratories, to the existing offering.
• In May 2025, RevoluGen announced that its mXpress1 Fire Monkey High Molecular Weight DNA extraction kits would be distributed in China, Hong Kong, and Taiwan by the biotechnology company ProteoQuest. The mXpress1 Fire Monkey High Molecular Weight DNA extraction kit is used in low-cost, short read and long read DNA sequencing experiments and genomic DNA extraction.
• In April 2025, QIAGEN launched three new automated sample preparation instruments: QIAsymphony Connect, QIAsprint Connect, and the QIAmini. These instruments are designed to increase the efficiency of nucleic acid preparation in high- and low-throughput labs on the QIAsymphony platform.
• January 2025: Applied BioCode, Inc., announced a release of additional nucleic acid extraction support for its BioCode Gastrointestinal Pathogen Panel on the ThermoFisher Scientific KingFisher Flex automated nucleic acid extraction platform, which will provide improvements in workflow and throughput for gastrointestinal testing in clinical laboratories.
• December 2024: In its statement, BiOptic Inc. announced that its nucleic acid extraction production business unit, operated by its completely-owned subsidiary OpenGene in the Xindian plant, has been successfully consolidated. The increased capacity of more than 50% and operational efficiencies will help to support the growth of the precision medicine, genetic testing, and clinical diagnostic markets.

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