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Bioorthogonal Handles: A New Frontier in Chemical Biology

Chemical biology is a rapidly evolving field that seeks to understand biological systems at the molecular level. One of the key challenges in this field is the ability to selectively modify or monitor biomolecules in complex biological environments. Recently, the concept of bioorthogonal handle has emerged as a powerful tool to address this challenge. In this article, we will explore what bioorthogonal handles are, how they work, their benefits, and their applications. We will also discuss the differences between bioorthogonal chemistry and click chemistry, a related but distinct concept. Finally, we will examine the incorporation of bioorthogonal handles into biomolecules.