Glycolysis in Cancer Therapy and Tumor Metabolism
Glycolysis
In normal cells under ideal conditions, glucose enters the cell via glucose transporters (GLUT). Through the action of key glycolytic enzymes such as hexokinase (HK) and phosphofructokinase (PFK), glucose is broken down to produce pyruvate. Pyruvate then enters the mitochondria, where it is converted to acetyl-CoA. This acetyl-CoA is oxidized through the tricarboxylic acid (TCA) cycle, generating 30 or 32 molecules of ATP.
