Creative Biostructure
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Creative Biostructure is specialized in providing cost-effective contract services to both academia and biotech/pharmaceutical industries in the field of structural biology and membrane protein technologies.
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Researchers Developed New Technology for cryo-structured Light Illumination and Electron Microscopy Correlation Imaging
Cryo-electron tomography (cryo-ET) for in situ structure analysis is a key technique for studying the in situ high-resolution structure of biomacromolecular complexes and their interactions. However, limited by the penetration ability of the electron beam, it is necessary to use the focused ion beam (cryo-FIB) to thin the cell and tissue samples into thin slices of about 200 nanometers before collecting cryo-ET data. Cryo-photonic correlation imaging technology can provide fluorescence positioning guidance for the precise preparation of cryo-FIB frozen aqueous sections containing specific target structures, but the optical resolution of the cryo-fluorescence microscope and the alignment accuracy of the light and electron microscope images are the key factors that restrict the success rate of the cryo-electrocorrelation experiment.
By Creative Biostructure3 years ago in Humans
Lipid Nanoparticles are Expected to "Show Their Talents"
In the fierce battle against COVID-19, lipid nanoparticles (LNP) have played an important role and attracted great attention. Nature reported on February 22 that in addition to being used to develop a new crown vaccine, LNP can also be used to treat diseases such as cancer, but scientists still face the challenges of reducing its toxicity and delivering it to suitable organs in the human body.
By Creative Biostructure3 years ago in Earth
