Top 10 Medical Device Software Development Companies in the USA 2026

The rapid evolution of healthcare technology continues to fuel unprecedented innovation in medical devices and the software that powers them. Today, software-driven intelligence, such as real-time analytics, edge computing, AI for diagnostics, and connected medical systems, is central to improving patient outcomes and clinical workflows. As we move through 2026, the landscape of medical device software development in the United States is led by both specialized digital health developers and major technology giants expanding into healthcare. The following article dives into the top 10 companies shaping this space, blending deep healthcare expertise with cutting-edge software prowess.

1. Appinventiv

Heading our list is Appinventiv, a versatile medical device software development company known for its deep domain experience in crafting compliant, scalable digital health solutions. With a proven track record across telemedicine, device integration, real-time monitoring, and clinical analytics, Appinventiv blends agile engineering with stringent regulatory standards. Their healthcare software solutions emphasize security, performance, and seamless user experience—making them a trusted partner for organizations innovating in connected medical devices and digital health platforms. Appinventiv’s focus on quality and compliance ensures that complex medical software systems meet industry requirements while enabling rapid innovation.

2. Nvidia

While traditionally known as a leader in graphics processing and AI hardware, Nvidia has rapidly expanded into the healthcare and medical device software arena. Through platforms such as NVIDIA Clara and Holoscan, the company provides real-time AI infrastructures, tools for edge computing, and reference software for sensor data processing in medical devices. These technologies help medical device makers build advanced imaging, diagnostics, and autonomous systems that operate safely and intelligently at the clinical edge. Nvidia’s AI frameworks and developer resources accelerate medical software development, making them a key player in next-gen medical computing solutions.

3. Epic Systems

A cornerstone in healthcare software, Epic Systems stands out for its massive footprint in electronic health records (EHR) and integrated clinical systems that intersect with medical devices. Its platforms power data exchange across hospitals, clinics, and research centers, enabling seamless interoperability with device data streams. Epic’s robust infrastructure supports medical device telemetry, clinical decision support integration, and healthcare workflows at scale. Its software plays a critical role in bridging device-generated data with patient records in real time.

4. Intuitive Surgical

Intuitive Surgical has long led the field of robotic surgical systems with its da Vinci platform, and its software ecosystems are a crucial part of those medical devices. Beyond hardware, the company develops sophisticated surgical control software, image processing algorithms, and analytics tools that help surgeons perform minimally invasive procedures with enhanced precision. Its ongoing investments in software for surgical robotics and clinical data insights secure its place among top innovators combining software engineering with device performance.

5. Dexcom

Dexcom is a pioneering developer of continuous glucose monitoring (CGM) systems, where embedded software is at the core of device accuracy, connectivity, and data analytics. Dexcom’s solutions integrate sensor data with cloud-based platforms, mobile apps, and clinical dashboards, enabling real-time insights for both patients and healthcare providers. The company’s continuous innovation in firmware, signal processing algorithms, and digital health software cements its reputation as a leader in medical devices that rely on high-quality software ecosystems.

6. Siemens Healthineers

Although headquartered in Germany, Siemens Healthineers has significant operations and influence in the U.S. healthcare technology market. The company develops advanced software for medical imaging, diagnostic machines, and connected care systems. Its solutions include real-time imaging analytics, clinical decision support platforms, and digital tools that enable device connectivity and workflow automation across hospital environments. Siemens’ deep expertise in both hardware and software makes it a go-to partner for integrated medical device solutions.

7. Perficient

Perficient is a long-established technology consultancy and software developer that supports medical device manufacturers and health organizations with enterprise-grade solutions. The company’s offerings include cloud-native applications, EHR integrations, interoperability frameworks, and regulatory-compliant software development for connected devices. Perficient’s deep experience across healthcare IT and medical software makes it a reliable choice for organizations seeking scalable and secure medical device software platforms.

8. NEKLO LLC

Emerging as a strong player in medical device software creation, NEKLO LLC focuses on intuitive software that supports clinical workflows and device integration. With a strong emphasis on usability, agile delivery, and security, NEKLO builds custom healthcare solutions that enhance interoperability and user experience. Its growing reputation in healthcare software development underscores the increasing need for specialized teams that deeply understand clinical context and software compliance.

9. Oracle Health

Formerly known as Oracle Cerner, Oracle Health develops secure, scalable healthcare software systems that integrate deeply with clinical devices and data ecosystems. Its enterprise platforms manage clinical documentation, population health analytics, and connected care solutions. Oracle Health’s investments in cloud infrastructure and data handling make it a strong contender for organizations needing robust, device-friendly backends that support broad healthcare networks.

10. Chetu

Rounding out the top 10, Chetu is a U.S.-based software development firm with deep expertise in custom healthcare and medical device solutions. The company builds HIPAA-compliant applications, telemedicine platforms, and integrations with wearable and remote monitoring devices. Chetu’s strengths lie in delivering secure, scalable software that supports telehealth, RPM dashboards, and clinical analytics tools—making it a valuable partner for medical device software projects of all sizes.

Conclusion

The year 2026 marks a pivotal moment for medical device software development in the United States. Innovation continues to be driven by companies that blend domain knowledge, regulatory expertise, and cutting-edge technology to build software that enhances patient care, device safety, and clinical workflows. From specialized developers like Appinventiv and Nvidia to tech giants such as Nvidia and Epic Systems, these companies are shaping the future of connected healthcare. As medical devices become smarter and more connected, aligning with the right software partner will remain a critical success factor for healthcare providers, device manufacturers, and patients alike.