Medicine

There is a problem with medicine. I'm missing something. This means that not only is it more difficult to find the cause of some diseases and find effective ways to treat them, some diseases are overlooked entirely. You may be the one missing, but we'll get to that in a moment. Because it's a story first. 8 billion stories to be exact. Indeed, our DNA is our body's instruction manual. But it is also a history book that chronicles our own unique genetic history. Our story all begins about 300,000 years ago when humans emerged in Africa. Some genetic stories tell of leaving for Europe, East Asia, or the Americas after hundreds of thousands of years. Some hereditary stories tell of the expansion of empires. Other diseases are diseases that we have evolved to prevent, and other diseases are the simple act of settling down and raising cows and drinking their milk. Each of us has a different genetic history, but perhaps not as different as you might expect. We share 99.9% of each other's DNA. Our story is 99.9% identical to her, but that 0.1% difference in her is incredibly powerful. This small difference in our genetic history has the potential to develop better treatments for disease, treatments that work for everyone. But medicine is not currently reading all these stories. To illustrate this, I would like to describe how researchers study the causes of disease and develop and test the efficacy and safety of new treatments. To figure out what causes a particular disease, researchers look for large numbers of people suffering from that disease and comb through their genetic histories. They look for small variations they share, small parts of the DNA story written differently. If they find something they will try all sorts of ways to deal with the effects. And when we find something that looks promising, we run clinical trials to see if it's real. In Phase 1, a small group of volunteers will attempt treatment. Well, often only half of them work and the other half get a placebo that doesn't work at all. If there are no significant side effects at the target dose, the treatment is approved and can proceed to the next stage of clinical trials. The second phase, this time with more participants, all suffer from ailments the researchers hope the drug can treat. If the drug seems to work, move on to Phase 3, where more participants will try the drug longer. Only then will new treatments be reviewed and hopefully approved for use by our general public. However, there is a problem with that. Here is the ethnicity of so many people that these days are used to find the cause of various diseases. And it can be compared with the ethnic diversity of the world's population. See the difference? The genetic histories investigated by researchers skew heavily toward those of people of European descent. This is because reading stories of people of mostly European descent in search of the causative pieces of DNA to target diseases for new drugs misses key parts of the stories told by various other groups. It means that there is a possibility. For example, it can change the risk of a disease or even reveal how the disease develops. For example, if scientists had only studied the stories of people of European descent, they might not have discovered the mutation that causes sickle cell aneFrom the early stages of research, the drug development process, to clinical studies. The good news is that more and more people are thinking about it. For example, cancer researchers at University College London studying genetic markers for cancer analyzed tissue samples from a wide range of ethnicities to ensure that the cancer biomarkers they identified were relevant to people of as many ethnicities as possible. I want to Conclusion:

Medicine must ensure the best possible library, one with the largest possible collection of genetic histories, so that it can consider the history of each individual, including one's own. This is the only way to ensure that everyone, wherever they are, has access to the best possible healthcare.

mia. And, importantly, it's not all that medicine lacks. For new treatments or medical treatments