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Uses

Medical

Various AAS and related compounds

Since the discovery and synthesis of testosterone in the 1930s, AAS have been used by physicians for many purposes, with varying degrees of success. These can broadly be grouped into anabolic, androgenic, and other uses.

Anabolic

Bone marrow stimulation: For decades, AAS were the mainstay of therapy for hypoplastic anemias due to leukemia, kidney failure or aplastic anemia.[9]

Growth stimulation: AAS can be used by pediatric endocrinologists to treat children with growth failure.[10] However, the availability of synthetic growth hormone, which has fewer side effects, makes this a secondary treatment.

Stimulation of appetite and preservation and increase of muscle mass: AAS have been given to people with chronic wasting conditions such as cancer and AIDS.[11][12]

Stimulation of lean body mass and prevention of bone loss in elderly men, as some studies indicate.[13][14][15] However, a 2006 placebo-controlled trial of low-dose testosterone supplementation in elderly men with low levels of testosterone found no benefit on body composition, physical performance, insulin sensitivity, or quality of life.[16]

Prevention or treatment of osteoporosis in postmenopausal women.[17][18] Nandrolone decanoate is approved for this use.[19] Although they have been indicated for this indication, AAS saw very little use for this purpose due to their virilizing side effects.[17][20]

Aiding weight gain following surgery or physical trauma, during chronic infection, or in the context of unexplained weight loss.[21][22]

Counteracting the catabolic effect of long-term corticosteroid therapy.[21][22]

Oxandrolone improves both short-term and long-term outcomes in people recovering from severe burns and is well-established as a safe treatment for this indication.[23][24]

Treatment of idiopathic short stature, hereditary angioedema, alcoholic hepatitis, and hypogonadism.[25][26]

Methyltestosterone is used in the treatment of delayed puberty, hypogonadism, cryptorchidism, and erectile dysfunction in males, and in low doses to treat menopausal symptoms (specifically for osteoporosis, hot flashes, and to increase libido and energy), postpartum breast pain and engorgement, and breast cancer in women.[27][28][29]

Androgenic

Androgen replacement therapy for men with low levels of testosterone; also effective in improving libido for elderly males.[30][31][32][33]

Induction of male puberty: Androgens are given to many boys distressed about extreme delay of puberty. Testosterone is now nearly the only androgen used for this purpose and has been shown to increase height, weight, and fat-free mass in boys with delayed puberty.[34]

Masculinizing hormone therapy for transgender men, other transmasculine people, and intersex people, by producing masculine secondary sexual characteristics such as a voice deepening, increased bone and muscle mass, masculine fat distribution, facial and body hair, and clitoral enlargement, as well as mental changes such as alleviation of gender dysphoria and increased sex drive